![]() ![]() The lab's work aims to determine the regulators that determine the conditions under which, and position(s) where, an RNA is capped in the cytoplasm. I am building a two-pronged collaborative basic science group that leverages RNA molecular biology tools with both specialized and traditional RNA sequencing approaches combined with long-read sequencing to elucidate how these RNA-mediated changes occur. The basic science research interests of the lab lie in the changes that occur in the RNA and molecular biology of cells when cellular stress responses converge to cause or exacerbate cardiovascular disease or cancer. This project is showing promise in cultured cancer cells and we are preparing to test the approach in animal models sometime in 2022. ![]() We are currently evaluating a handful of different mRNA-based strategies to counteract our targeted transcription factor. Since transcription factors are often considered ‘undruggable’ with traditional small molecule drugs, they are ideal targets for mRNA-based approaches. This RNA therapy approach is in its early stages.įinally, we are also generating traditional mRNA therapy constructs to target an overexpressed transcription factor in glioblastoma multiforme, the most lethal type of brain cancer. These RNA therapeutic candidates are designed to slow the course of the infection by interfering with the virus's replication machinery. In addition to our COVID-19 vaccine effort, we are developing candidate RNAs designed to treat active coronavirus disease. We continue to develop this platform and look for opportunities to expand the applications for our general design. With funding from the HMRI, we’ve been able to develop a customizable second-generation RNA vaccine platform which we are testing in multiple applications. In addition to the circular RNA mentioned above, the lab has also been developing a novel RNA vaccine platform for COVID-19 and other diseases. We continue working on this project and recently presented our intermediate findings as a talk titled “ Construction of circular RNAs to block miRNA-driven oncogenic transformation” during the Annual Meeting of the ASGCT on May 11, 2021. Kiss a Career Development Award from The American Society for Gene and Cell Therapy (ASGCT). Shortly after the lab opened, we began working on our first therapeutic candidate, an RNA designed to counter genes driving oncogenic transformation and cell migration in certain breast cancers. ![]() Houston Methodist Research Institute, Department of RNA Therapeutics and Cardiovascular Sciences () The Center for RNA Therapeutics is an independent program at the HMRI and is currently growing by recruiting multiple new faculty over the next few years. We are currently working with collaborators across the United Sates to test how our candidates compare to other existing vaccine systems. As part of the Center, the lab has developed novel vaccine candidates for COVID-19 and other human diseases. Specifically, as a founding lab of the HMRI’s Center for RNA Therapeutics we continue to develop innovative RNA therapy options to transform human health by generating new RNA therapies to treat (or prevent) different conditions. Namely, developing novel RNA Therapeutics to treat and/or prevent human disease and performing experiments to understand fundamental mechanisms concerning the RNA molecular biology of mammalian cells.Īs we are housed inside the Houston Methodist Research Institute (HMRI), the lab is committed to the translation of basic science discoveries to benefit human health. The Kiss RNA lab currently focuses on two main areas of research. ![]()
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![]() ![]() #Free adblock for safari ipad windows#Connectify Hotspot allows you to turn any Windows computer into an ad blocking WiFi hotspot and share the Internet with your iPhone or iPad. Instead of installing all kinds of rogue (and paid!) apps on your iPhone that run in the background, eating battery life and monitoring your web traffic, you can choose a simpler way. But still - how is it possible to get around and still block ads in apps on iPhone? Now - think about the apps you’re using - how often do you see ads in them and how much time you waste being forced (or not) to watch them?īrowser-based ad blockers (including Apple’s Safari) only take care of ads from websites, but what about the ads that are displayed within the apps you get from the Apple Store? Ads are not displayed in apps for nothing most of them monetize from ads, each time you click on an ad or register for a certain service. We did some tests a while ago and concluded that nearly 60% of web resources on major websites are ads! This means that if a page takes 5 seconds to fully load, 3 seconds of that are only the ads. To a limited degree, most modern browsers offer some type of ad blocking (especially for pop-up windows), but it’s often not enough. It's getting more and more difficult for visitors to get the information they want from a website that runs ads, and it can also slow down your iPhone's performance. Almost every website out there has ads, whether it’s in the form of web banners, photos, animations, videos, pop-up or pop-under windows, etc. ![]() ![]() ![]()
The system clears everything in the server just a few minutes after you exit the tool. But don’t worry if you didn’t erase them. You may delete them before leaving the website. Now save or use it in whichever way you want.Īfter converting the PDF to Word online, the files remain in our server temporarily. After navigating to the Word to PDF converter online, click Add File(s) to upload the Word doc required to convert to PDF. Press the “Download” button to obtain your new file. krok Wybierz opcj do pdf Wybierz format pdf lub inny potrzebny Ci format (sporód ponad 200 wspieranych formatów). To convert JPG JPEG PNG BMP GIF TIF TIFF to PDF, please, use the following link Image to PDF. krok Wczytaj plik/-i w formacie doc Wybierz pliki z komputera, dysku Google, usugi Dropbox, adresu URL lub po prostu przecignij plik na stron. To convert RTF ODT MHT HTM HTML TXT FB2 DOT DOTX XLS XLSX XLSB ODS XLT XLTX PPT PPTX PPS PPSX ODP POT POTX to PDF, please, use the following link Other documents to PDF. WORD TO PDF CONVERTER SOFTWAREIn case you inserted an encrypted file, the software will ask you to input the password to unlock the file.Īccessing the output file. To convert MS Word (DOC DOCX) to PDF, please, use the following link Word to PDF. Our tool will begin to convert pdf to editable word online, processing the file instantly. Browse through your folders and select the source file.Ĭonvert the PDF file to a Word document. Transfer PDF being modified to the open workspace. The site redirects to an open dialogue box where you perform PDF to Word modification. When you visit our website, hover your mouse over the various tools available for editing the document. Convert scanned PDF to Word efficiently using these straightforward steps: It won’t matter what the format of your PDFs is. WORD TO PDF CONVERTER TRIALAny unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription to that publication, where applicable -No cancellation of the current subscription is allowed during the active subscription period. -Any unused portion of a free trial period will be forfeited if you purchase a subscription to that.Using our service, modifying PDF to Word online has become an easy task.Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase.Account will be charged for renewal within 24-hours prior to the end of the current period, and identify the cost of the renewal. WORD TO PDF CONVERTER INSTALLAt 7.5 MB, it is a lightweight software that you can install in your Windows device running Windows XP. This includes files with special elements such as tables, fonts, graphics, etc.
![]() ![]() Released two years later, Hollywood Vampires managed to hold the audience's attention by peaking at number 42. Released in 1989 and propelled by the Top 40 single "The Ballad of Jayne," Cocked and Loaded went gold, giving the band a minor stake in the hair metal explosion that Guns N' Roses had helped spark. Guns quickly returned to the studio to bang out a second album, Cocked and Loaded. drummer Steve Riley joined the lineup during the tour that followed, and L.A. Guns released their self-titled debut album, featuring a raunchy, Aerosmith-influenced sound and a number of songs that had been written by ex-member Paul Black. Guns could enter the studio, though, and the rest of the lineup shifted as well, eventually solidifying around Guns, Lewis, drummer Nickey Alexander, bassist Kelly Nickels, and guitarist Mick Cripps. Black was replaced by former Girl frontman Phil Lewis before L.A. With Guns back in the lineup and Black writing most of the songs, the band landed a deal with Polygram Records and made plans to record a debut album. Guns, who'd continued playing shows in his absence under the leadership of vocalist Paul Black. Tracii Guns handled lead guitar duties for several months before being replaced by Slash suddenly finding himself without a band, he bounced back by rejoining his old bandmates in L.A. Rose and Guns decided to combine their two bands in 1985, thus creating the earliest incarnation of Guns N' Roses. Formed in 1983, the group's first lineup included Tracii Guns and vocalist Axl Rose, the latter of whom eventually left to form his own group with childhood friend Izzy Stradlin. Guns are also known for being one of the two bands (along with Hollywood Rose) that merged in the mid-'80s to form Guns N' Roses. If you’re a fan like me though you’ll no doubt want this but probably like me you’ll wish they’d just done a little bit more to reward you.Although veterans of the Sunset Strip's hair metal scene, L.A. ![]() Guns – ‘Almost all of Cocked and Loaded Live’ (or as an even more pedantic fan pointed out it should actually be called ‘Cocked & Loaded Live’.) Ironically of course in these days of streaming they’d both generate income!įor me in the end a record has to do what it says on the can and for me this is L.A. That raises a few questions – firstly it makes you wonder if they’re already writing off latest outing ‘The Devil You Know’ released in 2019? I’m mean ‘Speed’ is a decent song (and certainly ‘of the era’ sonically) but who wouldn’t rather have another of the songs from the ‘Cocked and Loaded’ era in there? Secondly why isn’t that two minute solo isn’t in here? Sure its pretty throwaway but it’s part of the album. More annoyingly perhaps for some there’s the shoe-horning in of recent song ‘Speed’ ( from 2017’s ‘Missing Peace’ album) between ‘Give a Little’ and ’17 Crash’ where the ‘I’m Addicted’ guitar solo was on the original record. So if you’re looking for a live version of that great album look no further…įor me though there’s a few niggles here such as the omission of the albums short and sweet opener ‘Letting Go’ – why? It’s a minute long song that I love to hear every time I play the record and one which I was even hoping they might expend here! The band also sounds great bearing in mind the months of inactivity that preceded it. In short just a straight to CD live set.Īs live albums go of course it’s got some pretty good material to run through so you can’t complain with songs like ‘Rip and Tear’, ‘Never Enough’, ‘The Ballad of Jayne’, ‘I Wanna Be Your Man’ and ‘Malaria’ all on here and all released as singles back in the day. There’s no extras, no other incentive to add this to your collection, not even the Eddie Trunk interview that preceded the stream. As those that listened in will know the set was streamed live globally and this is what you get here – a live CD of that set featuring two of the classic-era line up of the band. Guns record ‘Cocked & Loaded’ on the 31st Anniversary. Guns (t he Phil and Tracii version) took to the stage in Las Vegas to rip and tear through the classic second L.A. The pandemic of course has hit bands hard and no more so than those who make their living from relentless touring. ![]() ![]() ![]() Itunespy is a simple library to fetch data from the iTunes Store API made for Python 3.X. Store your palettes in an easy way, and edit them if needed ![]() This package contains client utilities and libraries.īackup and Restore your system using tar or Transfer it with rsync #Jottacloud backup full#FoundationDB is a scalable, fault-tolerant, ordered key-value store with full ACID transactions. Like always typing English in normal mode, but Chinese in insert mode.įoundationDB clients and library. Keep and restore fcitx state for each buffer separately when leaving/re-entering insert mode. Secure channel between network applications and keys stored in hardware tokensĪ unique physics-based ambient game (Humble Bundle/Store version)Įfficient, scalable and stable RDF databaseĪn IMAP/SMTP bridge to a ProtonMail account (patched, stores secrets in a file)Ī highly-available key value store for shared configuration and service discovery. Obtain and store AWS STS credentials to interact with Amazon services by authenticating via G Suite SAML. #Jottacloud backup mod#Measure and display the rate of data across a network connection or data being stored in a fileĪ bash-tool to store your private data inside a git repositoryĪ cloud service that lets you sync and share files anywhere.Ī simple and easy to use mod manager for several Unity games using Thunderstore.Įpic Asset Manager used to manage assets from Epic Games Store Web app for browsing, reading and downloading eBooks stored in a Calibre databaseĪn interactive menu to autotype and copy password-store and gopass data Whether you are an individual, family or business, Jottacloud lets you store, share and be productive wherever you are.Īn emergency tool to extract notes from the database where they're stored to plain files on the filesystem Tool for Snapshot RAID: generate parity files, maintain checksums on data, restore lost data Simple system backup and restore application with extra features Git-credential-keepassxc is a Git credential helper that allows Git (and shell scripts) to get/store logins from/to KeePassXCĪ free backup client that securely stores encrypted, incremental, compressed backups on cloud storage services and remote file serversĪn API for communicating with the Redis key-value store - no igbinary A Python 2 pytest plugin to store test expectations and mark tests based on themĬhromium web store extension (for ungoogled-chromium) ![]() ![]() ![]() ![]() Jean Ferris answers all these questions and more with OF SOUND MIND-a truly great book for people of all ages.Sound Mind Investing, found online at, is a company that calls themselves America's Premier Christian Financial Newsletter, "a kind of Consumer's Report for Christians" in finance.Īccording to their website, the creator of Sound Mind Investing saw the need to make a worthwhile source of information explained in an easy to understand format that could guide Christians through the investment process. What would it be like, I wondered, to be the only hearing person in my house? What would it take to forget about being a kid and take on the responsibilities at such a young age that Theo had to, like negotiating the buying of his hosue at age eleven? What would I do if I believed my family couldn't survive without me? When does something like being deaf stop defining who you are? OF SOUND MIND was such an interesting read, I didn't stop until I was finished. Soon things are finally running smoothly in Theo's household, until tragedy strikes yet again. Then Ivy comes up with a plan-what about having Harry and Hazel, a brother and sister that Ivy caters for, come and take care of Thomas? They've been learning sign language from Ivy, and they know enough to communicate. Theo is forced to do everything from making sure his brother gets fed and off to school to hiring new caretakers for his father every time his mother fires one. Suddenly, is demanding, diva-ish mother is acting even more incompetent than usual, refusing to even be alone in the same room as her husband once he comes home. Then tragedy strikes when Theo's dad has a stroke. Her dad, who builds model airplanes for a hobby, even gets Thomas and Jeremy interested, and soon they're getting together as often as they can. Ivy is a nurturer with her own small catering business, and soon her world is intwined with Theo's. Her father is deaf, but her mother, who abandoned the family long ago, was able to hear. For Theo, life is pretty much divided into two categories-talking with his voice to people who can hear, and talking with his hands to those who can't.īut then Theo meets Ivy, a girl in his school who can also hear and sign. His younger brother, Jeremy, needs Theo's help almost daily with his fifth-grade homework. Thomas hates asking Theo for anything, trying his best to communicate with hearing people on his own. His father, Thomas, is a furniture maker who was born being able to hear but lost his hearing later in life. His mother, Palma, is a famous sculptor, and she depends on Theo to make her phone calls, deal with galleries, and basically do anything and everything that she asks. Being the only hearing person in a family that includes a deaf father, deaf mother, and deaf younger brother has taken it's toll on Theo-he doesn't have his own life, not really, since he's always dealing with interpreting for his family. For Theo, dealing with deafness is simply a way of life. ![]() ![]()
big – big: Special file compression format used by Electronic Arts to compress the data for many of EA's games.BB – Is an 3D image file made with the application, Artlantis. #Unreal commander change drive letter icon orientation archive
![]() ![]() This app can also play various formats of audio, such as mp3, wma, wav, flac, dat, ac3, aac, ape, ogg, ra. More importantly, the playback is always auto-optimized to suit the preferred output device. It supports mp4, avi, flv, wmv, mkv, m4v, mov, rmvb, blu-ray, 4k, rmvb, swf and so on. ![]() #Stellarplayer softwareThis is a highly recommended software for those looking into free and powerful video tools.Īs a media player, of course, it should support many video and audio formats. While its settings aren’t too in-depth and there are some interface language issues here and there, the program’s performance itself is satisfactory and can be used for either work-related or leisure viewing. Versatile in its scopeĪll in all, StellarPlayer is a solid all-around media player for any type of user. This is a hassle as the default language is English while some of the labels on the controls are in Chinese-and you can’t fix them with a quick language interface change. However, while even the program’s theme can be changed, you can’t switch to another language. You can’t customize the subtitles themselves extensively through this but it does support formats like SRT, ASS, SSA, and SUB. The last one enables you to screencast-using DLNA projection to either receive feedback from other devices or cast videos to them wirelessly.Īside from these, you can configure various settings for this video player-such as recordings, screenshots, rendering, hotkeys, and video behavior. The four main buttons are Open File, Open Folder, Open URL, and Projection. You can hide the right panel with the arrow beside it or customize it using the Playlist Management feature. Upon launching, you’re greeted with two panes: the left one containing the main buttons you can use for quick playbacks and the right one containing your current playlist. This program’s high-speed motion compensation algorithm can even improve your videos’ playback to 60 FPS. Its decoding features multiple graphics cards and AI intelligence to help automatically select the right option for your hardware-such as auto-analysis of HDR videos for lower use of resources when playing them. The playback effect and audio direct output here are clear and smooth, avoiding any drop in the file’s quality thanks to its impressive CPU and GPU tuning technology. Plus, if you prefer streaming videos via website links, this software can handle them as well-offering protocols like HTTP, RTMP, UDP, and FTP. It can also play audio-only files like MP3, WMA, WAV, OGG, among others. It accepts popular video formats like MP4, AVI, FLV, WMV, MKV, HD, 4K, Blu-ray, and HDR. StellarPlayer falls easily enough into this category with just how many formats it can play. ![]() The core of a good video player application is its wide scope of support. However, its interface has a smattering of Chinese characters-which you can’t change to English. #Stellarplayer installIt also offers a variety of configurations and even the option to install supported plugins. Similar to other video players, StellarPlayer boasts clear and crisp graphics for your files, as well as smooth and low latency playback. Developed by Coldlake Technology (Wuhan) Co., Ltd., this multimedia program supports various media file formats, HD and 4K video playback, numerous streaming protocols, and even different subtitle formats. ![]() StellarPlayer is a free video player software that allows you to easily play and watch video files. ![]() ![]() ![]() Valerius Flaccus acknowledges her power : “Clio. What deeds, in the future, would society want to remember? Since she knew what deeds would make history, she was knowledgeable about the future. ![]() 630), he calls to the muse : “Begin thou, unforgetting Clio, for all the ages are in thy keeping, and all the storied annals of the past.” The Muses were goddesses with great power, and Clio was essential to the memory and future of mankind. Statius was a Roman epic writer who wished for his work to be untarnished by time. The common belief was that Clio could bless those she favored with historical immortality. “ kleio” means “to make famous/renowned”. She did this by making their deeds so unforgettable that they would be remembered throughout the eons. She had the power to immortalize anyone: whether they were heroes, poets, or politicians. Clio Clio, Muse of History, by Charles Meynier, 1800, via the Cleveland Art MuseumĬlio was the muse of history. Propertius says of Calliope in Elegies 3.2 : “The Musae (Muses) are my friends, my poems are dear to the reader, and Calliope never wearies of dancing to my rhythms.”Ģ. The belief was that if the muse was impressed by the skill of the bard, she would dance to it, and so bestow her favor on the creator. In ancient Greece, epic poetry was usually accompanied by music. Philostratus in his Imagines also comments on Calliope’s blessing, describing Orpheus thus: “charmed by his music even creatures that have not the intelligence of man, all the writers of myth agree.” According to Apollodorus, his singing and talent at the lyre was stirring enough to coax “stones and trees” to move. Her son, Orpheus, was blessed with her talent, and so he became an unparalleled musician. In older eras, Calliope’s role was recorded as encompassing music, song, and dance as well. Many a brave soul did it send hurrying down to Hades, and many a hero did it yield a prey to dogs and vultures, for so was the will of Zeus fulfilled…” ( Iliad, opening lines) “Sing, O goddess, the anger of Achilles son of Peleus, that brought countless ills upon the Achaeans. One of the most famous invocations of the muse is at the beginning of the epic poem, the Iliad. Many writers would invoke the power and support of Calliope when composing fantastical poetry about Greek heroes and their adventures. In artwork, she often appears carrying a scroll or a tablet with famous poetry inscribed upon it.Īs the oldest sister, she was the trailblazer of the Muses. Calliope Calliope, Muse of Epic Poetry, by Charles Meynier, 1798, via the Cleveland Art MuseumĬalliope was the muse of epic poetry and her name translates in ancient Greek as “beautiful-voice”. ![]() The invocation would begin, “Sing, O Muse…”, or “Sing, Goddess…”ġ. In poetic composition, ancient bards would invoke the muses to help them sing, narrate a story, or remember the great stories of heroes and heroines. Please check your inbox to activate your subscription Thank you! ![]() ![]() ![]() Running costs are reasonable and print speeds on plain paper are good, except for duplex prints. It’s easy to set up and use, thanks in part to its effective touchscreen controls, and produces very good quality prints and photos. The HP Photosmart 7520 is a well-designed all-in-one for home and home office use. The Canon PIXMA MG6350 is also a contender, with its ice-white case, twin trays and six-ink print, though it’s hampered by the unpredictable print times its continual housekeeping forces on it. At £130, though, there are other choices, such as the Epson Expression Photo XP-750 with faster photo prints and a useful CD/DVD tray. The printers 1200 dpi and individual ink. There are plenty of reasons to buy a Photosmart 7520, including its print quality, and feature set. The Photosmart 7520 Wireless Color e-All-In-One Inkjet Printer from HP prints up to 22 ppm in black and color. These are reasonable, compared with the competition, without turning any heads. The five ink cartridges are available in two capacities and using the XL versions gives pages costs of 3.0p for black and 8.1p for colour. Photos are bright, but never unnatural, with good rendition of detail in a range of hues. A full-colour copy is also unusually close to the original, though loses some definition. ![]() Colours on plain paper are bright and solid and even reversed text, white on black, is very readable. Print quality is very good, with clean, sharp text, looking close to laser quality. HP Photosmart 7520 – Print Quality and Costs Photo prints took between 1:02 and 1:27, depending on where we printed from, but even the slowest time is fine. The control panel offers 2-sided to 2-sided copies, but it turns out you have to feed the source sheets twice there’s no duplex scanning. Why doesn’t HP just tell you the page image is too big, so you can make your own adjustments?Ī colour copy from the flatbed took 22s and a 5-page black copy from the ADF took 1:02, both of which are reasonable. We assume this is because of increased print margins required by the duplexer, but other makes of printer don’t do it and it makes a nonsense of any form of page layout. The height and width is reduced by about 10 percent, in comparison with the same pages printed single-sided. This machine exhibits an old HP trait, where pages are automatically reduced in size when printed duplex. Few people will opt to print duplex, at less than a third the speed of single-sided print. ![]() The 5-page black text and colour graphic document gave only 5.7ppm, though, only just over half the rated speed and the 20-side, 10-page duplex test gave a slow 3.7 sides per minute. We saw 7.7ppm for our 5-page text test and this increased to 11.3ppm for the 20-page document, not far off spec. Although we didn’t reach those speeds under test, subjectively the printer seemed fast. HP rates the Photosmart 7520 at 14ppm for black print and 10ppm for colour. HP PHOTOSMART 7525 PRINTER REVIEWS FULLWe gladly provide a 100% satisfaction guarantee and full customer support for all products as we would like you to be completely satisfied with your order. We print hundreds of test pages to make sure your ink cartridges function properly. You can get all your printing done worry-free and without interruption when you purchase from 1ink. ![]() We use top quality materials and follow strict industry guidelines to produce the highest quality products.Īll our ink cartridges for HP PhotoSmart 7525 E AIO are carefully designed to provide an easy installation process and can save you time when you are ready to replace your old cartridges. Keep the print quality consistent and achieve superior results on every page. Choosing our discount replacement cartridges will help you reduce your printing expenses and save significantly on printer supplies. Order our discount HP PhotoSmart 7525 E AIO ink and enjoy an affordable printing solution. ![]() |
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